Were always talking about bud and how it effects you; today were going to talk about a huge key factor in understanding the benefits of correct dosage. A basic understanding of this will increase your medicines therapeutic effects. Some patients effectively use tiny amounts of cannabis, while others use incredibly high doses.
In a case study last year, adult patients achieved therapeutic effects at 1 mg of total cannabinoids daily, while others consume over 2,000 mg daily without adverse effects. And while a 2000-fold dosing range is unusual for a medication, researchers have failed to kill monkeys at doses even 300 times higher than the highest dose observed in any clinic.
Marijuana’s unusually broad dosing range exhibits an unexpected relationship between the dose and the expected response. Most medications, if you were to take a higher dose it would result in a stronger therapeutic effect and a higher likelihood of bad side effects. This is called the monophasic dose-response relationship. Cannabis just doesn’t follow this pattern!
Yes, for most cannabis consumers, in the beginning if they gradually increase their dose will most of the time have stronger effects. But after a certain point(unique to each individual) constant dosage will result in weaker and weaker therapeutic effects.
Consumers that continue to increase their dosage to high levels can often reclaim some or all of the previously lost benefit, and sometimes find additional therapeutic effects not achieved at the lower doses. Of course, ultra-high doses are much more expensive and usually produce more unwanted side effects. Most patients do much better at the lowest effective dose.
The term “therapeutic window” comes into play and it describes the range between the lowest effective dose and the dose that produces unwanted or intolerable side effects. People who have little or no experience using cannabis usually have a very narrow therapeutic window, while regular users develop a wider therapeutic window.
This is due to the fact that individuals build tolerance to the various effects of cannabis at different rates, and most build tolerance to the unwanted effects faster than the desired effects. Cannabis also has the ability to produce opposite effects in different people, with different strains, and at different dosages.
For example, anxious people who take cannabis may relax while non-anxious people who take the same dose can become anxious. The same dose of two different varieties of cannabis can cause opposite effects – one might be an awakening strain and the other might put you to sleep.
Fortunately, these symptoms are all self-limiting, and most people return to their normal state of mind within 12 to 24 hours. Even though a cannabis overdose may make a person feel like they’re dying, such an experience will cause no toxicity or permanent damage, except perhaps in people who have unstable cardiovascular or psychiatric conditions, or in the case of impairment leading to an accident.
All in all though, it really depends on the person in question. Some people do well with super high dosages, but they slowly work up to these. But majority of people do very well with a smaller dosage.
Most people are surprised to learn that the therapeutic effects of cannabis can be achieved at dosages lower than those required to produce euphoria or impairment. Cannabis microdosing, taking a non- or slightly psychoactive dose for the purpose of improving heath and productivity, has been gaining popularity.
So this is what I want you to do, next time your about to medicate take a smaller amount. Maybe start off with a week break to kill your tolerance, then when you come back try to use less. It might sound crazy but youll be glad you did it. You will get to your medicated state faster and cheaper. Doesn’t that sound nice, go try it out and come back and tell me what you think. Hope to hear from you soon.